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KMID : 0525720120170040204
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Journal of Chitin and Chitosan
2012 Volume.17 No. 4 p.204 ~ p.209
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Effect of Deep Sea Water Containing Chitosan Oligosaccharides on Lipid Metabolism
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Park Jung-Eun
Shin Eun-Ji
Ha Byung-Geun
So Myung-Suk
Shon Yun-Hee
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Abstract
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Effect of deep sea water (DSW) containing chitosan oligosaccharides (COS) on lipid metabolism, lipogenesis and lipolysis, was studied in differentiated 3T3-L1 adipocytes, We investigated expression levels of lipogenic genes like sterol regulatory element-binding protein 1c (SREBP1c) and fatty acid synthase (FAS), and lipolytic genes like hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) using RT-PCR, DSW with or without COS inhibited adipocyte differentiation, expressions of lipogenic and lipolytic genes in a dose-dependent manner. These data suggest that DSW containing COS is effective in decreasing lipid metabolism by the regulation of lipogenic and lipolytic gene expressions.
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KEYWORD
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Chitosan oligosaccharide, Deep sea water, Adipogenesis, Lipogenesis, Lipolysis
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